Skin Prick Test Predictive Values for the Outcome of Cashew Challenges in Children

V McWilliam; RL Peters; KJ Allen; SC Dharmage; AL Ponsonby; MLK Tang; J Smart; K Perrett; D Tey; M Robinson; M Taranto; JJ Koplin; LC Gurrin; T Dwyer; A Lowe; M Wake; C Robertson; S Sawyer; G Patton; J Douglass; P Vuillermin

Journal article

Skin Prick Test Predictive Values for the Outcome of Cashew Challenges in Children

V McWilliam, RL Peters, KJ Allen, SC Dharmage, AL Ponsonby, MLK Tang, J Smart, K Perrett, D Tey, M Robinson, M Taranto, JJ Koplin, LC Gurrin, T Dwyer, A Lowe, M Wake, C Robertson, S Sawyer, G Patton, J Douglass Show all

Journal of Allergy and Clinical Immunology in Practice | ELSEVIER | Published : 2020

DOI: 10.1016/j.jaip.2019.05.057

Abstract

Background: Cashew is a common cause of tree nut allergy in children. To date there have been few studies of diagnostic tests for cashew allergy, and positive predictive values (PPVs) for cashew as well as other tree nuts are largely extrapolated from studies of peanut allergy. How relevant these cutoffs are for cashew has not been formally explored. Objective: We aimed to establish skin prick test (SPT) wheal sizes that correlated to 95% PPV for a positive food challenge for cashew. Methods: We included all cashew oral food challenges (OFCs) conducted as part of the HealthNuts (n = 108; age, 4-6 years) and SchoolNuts (n = 37; age, 10-14 years) studies, both recruited from the community (pop..

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University of Melbourne Researchers

Rachel Peters Author

Shyamali Dharmage Author

Anne-Louise Ponsonby Author

Mimi Tang Author

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Grants

Awarded by Center for AIDS Research, Emory University

Funding Acknowledgements

This study is supported by funding from the National Health and Medical Research Council (NHMRC) of Australia (HealthNuts study ID 1006215 and SchoolNuts study ID 1047396), the Australian Food Allergy Foundation, the Victorian Government's Operational Infrastructure Support Program, and the NHMRC Centre for Food and Allergy Research (ID 1041420). K. J. Allen, S. C. Dharmage, A.-L. Ponsonby, L. C. Gurrin, J. J. Koplin and R. L. Peters hold National Health and Medical Research Council (NHMRC) awards. V. McWilliam received a PhD scholarship from the NHMRC-funded Centre for Food Allergy Research (CFAR). K. Perrett holds a Melbourne Children's Clinician Scientist Fellowship.